Single chain antibody against the common epitope of mutant p53 restores wild-type activity to mutant p53 protein

Author:

Orgad Sara,Goldfinger Naomi,Cohen Gerald,Rotter Varda,Solomon Beka

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference34 articles.

1. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes;Hussain;Cancer Res.,1998

2. Rescuing the function of mutant p53;Bullock;Nat. Rev. Cancer,2001

3. The tumor suppressor gene TP53: implications for cancer management and therapy;Seemann;Crit. Rev. Clin. Lab. Sci.,2004

4. Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations;Brachmann;EMBO J.,1998

5. Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations;Nikolova;EMBO J.,2000

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