Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors

Author:

Tholander Fredrik,Roques Bernard-Pierre,Fournié-Zaluski Marie-Claude,Thunnissen Marjolein M.G.M.,Haeggström Jesper Z.

Funder

Swedish Research Council

Linneus Grant CERIC

CIDaT

EC FP6

FP7

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference37 articles.

1. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation;Samuelsson;Science,1983

2. Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice;Griffiths;J. Exp. Med.,1997

3. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities;Bailie;J. Immunol.,1996

4. The PPARα-leukotriene B4 pathway to inflammation control;Devchand;Nature,1996

5. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene;Chen;Nature,1994

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