Effect of Modifier Structure on the Activation of Leukotriene A4 Hydrolase Aminopeptidase Activity-Reference-Cited by-同舟云学术

Effect of Modifier Structure on the Activation of Leukotriene A4 Hydrolase Aminopeptidase Activity

Published:2019-11-21 Issue:23 Volume:62 Page:10605-10616
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lee Kyung Hyeon¹²^ORCID,Petruncio Greg¹,Shim Amanda³,Burdick Marie³,Zhang Zhimin³,Shim Yun M.³,Noble Schroeder M.²,Paige Mikell¹

Affiliation:

1. Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, Virginia 20110, United States

2. Bacterial Diseases Branch, Wound Infections Department, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States

3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, P.O. Box 800546, Charlottesville, Virginia 22908, United States

Funder

National Heart, Lung, and Blood Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00663

Reference42 articles.

1. Role of Leukotriene A4 Hydrolase Aminopeptidase in the Pathogenesis of Emphysema

2. Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase

3. Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis

4. The development of novel LTA4H modulators to selectively target LTB4 generation

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