Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation-Reference-Cited by-同舟云学术

Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

Published:2011-02-05 Issue:5 Volume:585 Page:730-736
ISSN:0014-5793
Container-title:FEBS Letters
language:en
Short-container-title:

Author:

Otomo Asako,Kunita Ryota,Suzuki-Utsunomiya Kyoko,Ikeda Joh-E,Hadano Shinji

Funder

Scientific Research from the Japan Society for the Promotion of Science

Japan Science and Technology Agency

Ministry of Health, Labor and Welfare

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.febslet.2011.01.045/fullpdf

Reference17 articles.

1. Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration;Hadano;Neurochem. Int.,2007

2. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2;Hadano;Nat. Genet.,2001

3. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis;Yang;Nat. Genet.,2001

4. ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics;Otomo;Hum. Mol. Genet.,2003

5. Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor;Topp;J. Biol. Chem.,2004

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