Synthesis of diazaquinomycin a and b: the first double knorr cyclization

Author:

Kelly T.Ross,Field Jeffrey A.,Li Qun

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference11 articles.

1. The structures of diazaquinomycins a and b, new antibiotic metabolites

2. Nybomycin. VII. Preparative routes to nybomycin and deoxynybomycin

3. Acids examined include cone. H2SO4, 30% oleum, conc. H2SO4/P2O5, 85% H3PO4, PPA, CF3COOH, liquid HF, HBr/HOAc, CF3SO3H, CF3SO3H/SbF5/CF3COOH, TiCl4, BF3·Et2O and BBr3,. Thennolyses neat and in refluxing diphenyl ether were also unsuccessful.

4. Alkylation of dianions of .beta.-keto esters

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