Total synthesis of diazaquinomycins H and J using double Knorr cyclization in the presence of triisopropylsilane
Author:
Affiliation:
1. Department of Pharmaceutical Sciences
2. The Daniel K. Inouye College of Pharmacy
3. University of Hawaii at Hilo
4. Hilo
5. USA
Abstract
The first total syntheses of antitubercular diazaquinomycins H (1) and J (2) were achieved in 25% and 21% overall yields, respectively.
Funder
Hawaii Community Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C8RA09792E
Reference39 articles.
1. Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis
2. Diazaquinomycins E–G, Novel Diaza-Anthracene Analogs from a Marine-Derived Streptomyces sp.
3. Isolation and structure elucidation of Diazaquinomycin C from a terrestrial streptomyces sp. and confirmation of the akashin structure
4. OM-704A, a new antibiotic active against gram-positive bacteria produced by Streptomyces sp.
5. The structures of diazaquinomycins a and b, new antibiotic metabolites
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