Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death

Author:

Yan Bo,Ding Zhangcheng,Zhang Wenbin,Cai Gaihong,Han Hui,Ma Yan,Cao Yang,Wang Jiawen,Chen She,Ai YouweiORCID

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity;Ai;Nat. Commun.,2020

2. PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth;An;Am. J. Cancer Res.,2019

3. Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond;Baillie;Nat. Rev. Drug Discov.,2019

4. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms;Beavo;Physiol. Rev.,1995

5. Inhibition of phosphodiesterases as a strategy to achieve neuroprotection in Huntington’s disease;Cardinale;CNS Neurosci. Ther.,2018

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