Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors

Author:

Weigt David,Parrish Cynthia A.,Krueger Julie A.,Oleykowski Catherine A.,Rendina Alan R.,Hopf Carsten

Funder

BMBF

Deutsche Forschungsgemeinschaft

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference45 articles.

1. Adams, N.D. (2011). Triazolones as fatty acid synthase inhibitors. World Intellectual Property Organization WO2011103546.

2. Fasnall, a selective FASN inhibitor, shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) breast cancer;Alwarawrah;Cell Chem. Biol.,2016

3. Single-cell MALDI-MS as an analytical tool for studying intrapopulation metabolic heterogeneity of unicellular organisms;Amantonico;Anal. Chem.,2010

4. Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors;Angeles;Expert Opin. Drug Discov.,2016

5. Integration of an in situ MALDI-based high-throughput screening process: a case study with receptor tyrosine kinase c-MET;Beeman;SLAS Discov.,2017

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