Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of Paclitaxel

Author:

Matesanz Ruth,Barasoain Isabel,Yang Chun-Gang,Wang Lei,Li Xuan,de Inés Concepción,Coderch Claire,Gago Federico,Barbero Jesús Jiménez,Andreu José Manuel,Fang Wei-Shuo,Díaz José Fernando

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference33 articles.

1. Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein;Brooks;Mol. Cancer Ther.,2003

2. Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity;Buey;Chem. Biol.,2004

3. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity;Buey;Chem. Biol.,2005

4. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites;Buey;Nat. Chem. Biol.,2007

5. Synthesis of 7-deoxytaxol and 7,10-dideoxytaxol via radical intermediates;Chen;J. Org. Chem.,1993

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