Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction

Author:

Lafferty Ryan A.,Tanday Neil,Flatt Peter R.,Irwin Nigel

Funder

Invest Northern Ireland

University of Ulster

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference44 articles.

1. Emerging therapeutic potential for peptide YY for obesity-diabetes;Lafferty;Peptides,2018

2. PYY(1–36) peptides from phylogenetically ancient fish targeting mammalian NPY1 receptors demonstrate potent effects on pancreatic beta-cell function, growth and survival;Lafferty;Diabetes Obes. Metab.,2019

3. Peptide yy: intrapancreatic localization and effects on insulin and glucagon secretion in the mouse;Bottcher;Pancreas,1989

4. Islet distribution of peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival;Khan;Mol. Cell. Endocrinol.,2016

5. PYY-dependent restoration of impaired insulin and glucagon secretion in type 2 diabetes following roux-en-Y gastric bypass surgery;Ramracheya;Cell Rep.,2016

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