Tethered spheroids as an in vitro hepatocyte model for drug safety screening

Author:

Xia Lei,Sakban Rashidah Binte,Qu Yinghua,Hong Xin,Zhang Wenxia,Nugraha Bramasta,Tong Wen Hao,Ananthanarayanan Abhishek,Zheng Baixue,Chau Ian Yin-Yan,Jia Ruirui,McMillian Michael,Silva Jose,Dallas Shannon,Yu Hanry

Publisher

Elsevier BV

Subject

Mechanics of Materials,Biomaterials,Biophysics,Ceramics and Composites,Bioengineering

Reference52 articles.

1. Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages;Giri;Expert Opin Drug Metab Toxicol,2010

2. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies;Hewitt;Drug Metab Rev,2007

3. Mechanisms of hepatotoxicity;Jaeschke;Toxicol Sci,2002

4. Guideline for industry: drug interaction studies - study design, data analysis, and implications for dosing and labeling;U.S. Food and Drug Administration,2006

5. Guideline on the investigation of drug interactions;European Medicines Agency,2010

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