Microwave-assisted synthesis of aminopyrimidines
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference6 articles.
1. For example, 2-anilinopyrimidines as CRF antagonists: Arvanitis, A. G.; Gilligan, P. J. G.; Chorvat, R. J.; Cheeseman, R. S.; Christos, T. E.; Bakthavatchalam, R.; Beck, J. P.; Cocuzza, A. J.; Hobbs, F. W.; Wilde, R. G.; Arnold, C.; Chidester, D.; Curry, M.; He, L.; Hollis, A.; Klaczkiewicz, J.; Krenitsky, P.; Rescinito, J. P.; Scholfield, E.; Culp, S.; De Souza, E. B.; Fitzgerald, L.; Grigoriadis, D.; Tam, S. W.; Wong, Y. N.; Huang, S.; Shen, H. J. Med. Chem. 1999, 42, 805–818.
2. Some recent publications on the pyrimidine syntheses: (a) Moffat, D.; Davis, P.; Hutchings, M.; Davis, J.; Berg, D.; Batchelor, M.; Johnson, J.; O'Connel, J.; Martin, R.; Crabbe, T.; Delgado, J.; Perry, M. Bioorg. Med. Chem. Lett. 1999, 9, 3351–3356; (b) Cocuzza, A. J.; Hobbs, F. W.; Arnold, C. R.; Chidester, D. R.; Yarem, J. A.; Culp, S.; Fitzgerald, L.; Gilligan, P. J. Bioorg. Med. Chem. Lett. 1999, 9, 1057–1062; (c) Kumagai, T.; Okubo, T.; Kataoka-Okubo, H.; Chaki, S.; Okuyama, S.; Nakazato, A. Bioorg. Med. Chem. 2001, 9, 1349–1356; (d) Brown, G. R.; Hollinshead, D. M.; Stokes, E. S. E.; Waterson, D.; Clarke, D. S.; Foubister, A. J.; Glossop, S. C.; McTaggart, F.; Mirrless, D. J.; Smith, G. J.; Wood, R. J. Med. Chem. 2000, 43, 4964–4972; (e) Kanda, Y.; Kawanishi, Y.; Oda, K.; Sakata, T.; Mihara, S.; Asakura, K.; Kanemasa, T.; Ninomiya, M.; Fujimoto, M.; Konoike, T. Bioorg. Med. Chem. 2001, 9, 897–907; (f) Nagai, S.; Miyachi, T.; Nakane, T.; Ueda, T.; Uozumi, Y. J. Heterocycl. Chem. 2001, 38, 379–382.
3. For recent reviews, see: (a) Perreux, L.; Loupy, A. Tetrahedron 2001, 57, 9199–9223; (b) Larhed, M.; Hallberg, A. Drug Disc. Today 2001, 6, 406–416; (c) Wathey, B.; Tierney, J.; Lidstrom, P.; Westman, J. Drug Disc. Today 2002, 7, 373–380.
4. Some recent reactions facilitated by microwave irradiations. Synthesis of heterocycles: triazoles: (a) Bentiss, F.; Lagrenee, M.; Barby, D. Tetrahedron Lett. 2000, 41, 1539–1541. Thiazoloquinazolines: (b) Besson, T.; Guillard, J.; Rees, C. W. Tetrahedron Lett. 2000, 41, 1027–1030. Quinolines: (c) Ranu, B. C.; Hajra, A.; Jana, U. Tetrahedron Lett 2000, 41, 531–533. Oxazoles: (d) Lee, J. C.; Song, I.-G. Tetrahedron Lett. 2000, 41, 5891–5894. Imidazoles: (e) Usyatinsky, A. Y.; Khmelnitsky, Y. L. Tetrahedron Lett. 2000, 41, 5031–5034. Reaction types: Asymmetric hydrogen transfer: (f) Lutsenko, S.; Moberg, C. Tetrahedron: Asymmetry 2001, 12, 000–000. Esterifications: (g) Kabza, K. G.; Chapados, B. R.; Gestwicki, J. E.; McGrath, J. L. J. Org. Chem. 2000, 65, 1210–1214. Sonogashira coupling: (h) Kabalka, G. W.; Wang, L.; Namboodiri, V.; Pagni, R. M. Tetrahedron Lett. 2000, 41, 5151–5154. Thia-Fries rearrangement: (i) Moghaddam, F. M.; Dakamin, M. G. Tetrahedron Lett. 2000, 41, 3479–3481. Wittig reaction: (j) Frattini, S.; Quai, M.; Cereda, E. Tetrahedron Lett. 2001, 42, 6827–6829. Mitsunobu reactions: (k) Steinreiber, A.; Stadler, A.; Mayer, S. F.; Faber, K.; Kappe, C. O. Tetrahedron Lett. 2001, 42, 6283–6286. Suzuki couplings: (l) Blettner, C. G.; Konig, W. A.; Stenzel, W.; Schotten, T. J. Org. Chem. 1999, 64, 3885–3890; (m) Villemin, D.; Gomez-Escalonilla, M. J.; Saint-Clair, J.-F. Tetrahedron Lett. 2001, 42, 635–637; (n) Villemin, D.; Caillot, F. Tetrahedron Lett. 2001, 42, 639–642.
5. Improved yields of meta-amination and symmetrical and unsymmetrical diamination of benzenes
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