4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70-Reference-Cited by-同舟云学术

4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70

Published:1999-12 Issue:23 Volume:9 Page:3351-3356
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Moffat David,Davis Peter,Hutchings Martin,Davis Jeremy,Berg Daniel,Batchelor Mark,Johnson James,O'Connell James,Martin Richard,Carabbe Tom,Delgado Jean,Perry Martin

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Partially disclosed in Davis, P.D.; Davis, J.M.; Moffat, D.F.C.; Hutchings, M.C., International Patent Specification No. WO 97/19065, 1997.

2. Complex Complexes: Signaling at the TCR

3. ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

4. Essential role for ZAP-70 in both positive and negative selection of thymocytes

5. Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

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