Facile access to 2′-O-acyl prodrugs of 1- (β-d-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2′ 3′, 5′-triesters1-Reference-Cited by-同舟云学术

Facile access to 2′-O-acyl prodrugs of 1- (β-d-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2′ 3′, 5′-triesters1

Published:1993-05 Issue:19 Volume:34 Page:3177-3180
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Baraldi Pier G.,Bazzanini Rita,Manfredini Stefano,Simoni Daniele,Robins Morris J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference13 articles.

1. Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs

2. Improvement of the bioavailability of the anti-herpes virus agent BVDU by use of 5′-0-alkoxycarbonyl derivatives with increased metabolic stability

3. Conversion of vinylsilanes to vinyl halides with xenon difluoride and metal halides. A versatile new route to 5-(2-halovinyl)pyrimidine nucleosides

4. Nucleic acid related compounds. 65. New syntheses of 1-(.beta.-D-arabinofuranosyl)-5(E)-(2-iodovinyl)uracil (IVAraU) from vinylsilane precursors. Radioiodine uptake as a marker for thymidine kinase herpes viral infections

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