Convenient two-step stereospecific hydroxy-substitution with retention in β-hydroxy-δ-lactones. 4 ()-heterosubstituted mevinolin and -analogs
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference13 articles.
1. Synthetic and biological studies of compactin and related compounds. 4. Total synthesis of (+)-compactin
2. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted-[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives
3. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives
4. A report on compounds 2, including experimental details of the synthesis of 3a,b is in preparation for J. Med. Chem..
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