Can MSH3 lowering stop HTT repeat expansion in its CAG tract?
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine
Reference12 articles.
1. Identification of genetic variants associated with Huntington’s disease progression: a genome-wide association study;Moss;Lancet Neurol.,2017
2. CAG repeat not polyglutamine length determines timing of huntington’s disease onset;Genetic Modifiers of Huntington’s Disease GeM-HD Consortium;Cell,2019
3. Di-valent siRNA mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease;O'Reilly;Mol. Ther.,2023
4. A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system;Alterman;Nat. Biotechnol.,2019
5. MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1;Flower;Brain.,2019
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