Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine
Reference63 articles.
1. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities;Tabrizi;Nat. Rev. Neurol.,2020
2. Therapies targeting DNA and RNA in Huntington's disease;Wild;Lancet Neurol.,2017
3. Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities;Tabrizi;Lancet Neurol.,2022
4. Clinical features of huntington’s disease;Ghosh,2018
5. Huntington's disease: a clinical review;McColgan;Eur. J. Neurol.,2018
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1. Length-independent and selective sensing of CCG trinucleotide repeat foldings by a monovalency-binding fluorogenic probe;Sensors and Actuators B: Chemical;2024-02
2. Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice;Scientific Reports;2024-01-24
3. A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system;2023-12-19
4. A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s disease;2023-12-15
5. Therapeutic validation of MMR-associated genetic modifiers in a humanex vivomodel of Huntington’s disease;2023-12-07
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