Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier-Reference-Cited by-同舟云学术

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

Published:2018-11 Issue:11 Volume:26 Page:2580-2591
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Godinho Bruno M.D.C.,Henninger Nils,Bouley James,Alterman Julia F.,Haraszti Reka A.,Gilbert James W.,Sapp Ellen,Coles Andrew H.,Biscans Annabelle,Nikan Mehran,Echeverria Dimas,DiFiglia Marian,Aronin Neil,Khvorova Anastasia

Funder

CHDI Foundation

NIH

Milton-Safenowitz Fellowship

Amyotrophic Lateral Sclerosis Association

National Institute of Neurological Disorders and Stroke

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference48 articles.

1. 5′-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo;Haraszti;Nucleic Acids Res.,2017

2. Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo;Hassler;Nucleic Acids Res.,2018

3. Targeting of antithrombin in hemophilia A or B with RNAi therapy;Pasi;N. Engl. J. Med.,2017

4. Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol;Ray;N. Engl. J. Med.,2017

5. Hydrophobically modified siRNAs silence Huntingtin mRNA in primary neurons and mouse brain;Alterman;Mol. Ther. Nucleic Acids,2015

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