A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism-Reference-Cited by-同舟云学术

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A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism

Published:2017-07 Issue:7 Volume:25 Page:1531-1543
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Meng Yu,Wiseman Jennifer A.,Nemtsova Yuliya,Moore Dirk F.,Guevarra Jenieve,Reuhl Kenneth,Banks William A.,Daneman Richard,Sleat David E.,Lobel Peter

Funder

NIH

Zhejiang Provincial Natural Science Foundation of China

Batten Disease Support and Research Association

Cures Within Reach

Noah’s Hope

Hope 4 Bridget

Fight for Nicolas

Jasper Against Batten

NIEHS Center

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference44 articles.

1. Therapeutic approaches for neuronopathic lysosomal storage disorders;Schiffmann;J. Inherit. Metab. Dis.,2010

2. Clarifying lysosomal storage diseases;Schultz;Trends Neurosci.,2011

3. Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain;Meng;Mol. Ther.,2014

4. A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration;Sleat;J. Neurosci.,2004

5. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis;Sleat;Science,1997

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4. K16ApoE inhibits the activity of acetylcholinesterase but is not the primary toxicological mechanism in mice;Fundamental Toxicological Sciences;2023

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