Design, synthesis and preliminary evaluation of novel 3′-Substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors-Reference-Cited by-同舟云学术

Design, synthesis and preliminary evaluation of novel 3′-Substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors

Published:2001-12 Issue:24 Volume:11 Page:3179-3182
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Pellicciari Roberto,Costantino Gabriele,Marinozzi Maura,Macchiarulo Antonio,Amori Laura,Josef Flor Peter,Gasparini Fabrizio,Kuhn Rainer,Urwyler Stephan

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets

2. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells

3. Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine. Focus on (2S,1‘S,2‘S,3‘R)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist

4. Asymmetric synthesis of enantiomerically pure (2S,1′S,2′S,3′R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors

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