Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine. Focus on (2S,1‘S,2‘S,3‘R)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine. Focus on (2S,1‘S,2‘S,3‘R)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist

Published:1996-01-01 Issue:11 Volume:39 Page:2259-2269
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pellicciari Roberto¹,Marinozzi Maura¹,Natalini Benedetto¹,Costantino Gabriele¹,Luneia Roberto¹,Giorgi Gianluca¹,Moroni Flavio¹,Thomsen Christian¹

Affiliation:

1. Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06123 Perugia, Italy, Centro Interdipartimentale di Analisi e Determinazioni Strutturali, Università di Siena, Via P. A. Mattioli 10, 53100 Siena, Italy, Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale G. B. Morgagni 65, 50134 Firenze, Italy, and Health Care Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960059%2B

Reference53 articles.

1. Excitatory amino acid neurotoxicity and neurodegenerative disease

2. A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation

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