Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU)-Reference-Cited by-同舟云学术

Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU)

Published:2001-09 Issue:17 Volume:11 Page:2225-2228
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ludovici Donald W.,Kukla Michael J.,Grous Philip G.,Krishnan Suma,Andries Koen,de Béthune Marie-Pierre,Azijn Hilde,Pauwels Rudi,De Clercq Erik,Arnold Edward,Janssen Paul A.J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

2. Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives

3. Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

4. Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

5. A check on rational drug design: Molecular simulation of the allosteric inhibition of HIV-1 reverse transcriptase

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