Arylbiamidines: synthesis and structural studies en route to anticancer applications
Author:
Affiliation:
1. Institut de Chimie de Nice CRNS UMR7272
2. Université Côte d’Azur
3. Nice
4. France
5. Centre Méditerranéen de Médecine Moléculaire (C3M)
6. INSERM
7. U1065
8. Department of Chemical and Biochemical Sciences
Abstract
Four novel arylbiamidine series were studied showing particular tautomerism and H-bonding structure highlighting their promising druglike features toward anticancer applications.
Funder
Canceropôle PACA
Université Côte d’Azur
Centre National de la Recherche Scientifique
Agence Nationale de la Recherche
Institut National Du Cancer
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ01943K
Reference25 articles.
1. “What's in a structure?” The story of biguanides
2. Amidine functionality as a stimulus-responsive building block
3. Amidines, isothioureas, and guanidines as nucleophilic catalysts
4. Biological activities of guanidine compounds, 2008 – 2012 update
5. The chemistry and biology of guanidine natural products
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