Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals-Reference-Cited by-同舟云学术

Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals

Published:2002-09 Issue:18 Volume:12 Page:2515-2518
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Seward Eileen M,Carlson Emma,Harrison Timothy,Haworth Karen E,Herbert Richard,Kelleher Fintan J,Kurtz Marc M,Moseley Jonathan,Owen Simon N,Owens Andrew P,Sadowski Sharon J,Swain Christopher J,Williams Brian J

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Identification of a Series of 3-(Benzyloxy)-1-azabicyclo[2.2.2]octane Human NK1 Antagonists

2. Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

3. Reduction of Cisplatin-Induced Emesis by a Selective Neurokinin-1–Receptor Antagonist

4. Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

5. 1,7-Dioxaspiro[5.5]undecanes. An excellent system for the study of stereoelectronic effects (anomeric and exo-anomeric effects) in acetals

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