Pyrrolo[2,3-d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II-Reference-Cited by-同舟云学术

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Pyrrolo[2,3-d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II

Published:2000-10 Issue:19 Volume:10 Page:2171-2174
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Burchat Andrew F,Calderwood David J,Hirst Gavin C,Holman Nicholas J,Johnston David N,Munschauer Rainer,Rafferty Paul,Tometzki Gerald B

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

2. Arnold, L. D.; Calderwood, D. J.; Dixon, R.; Johnston D. N.; Kamens, J. S.; Rafferty, P.; Ratnofsky, S. E. Bioorg. Med. Chem. Lett. Preceeding paper in this journal (Bioorg. Med. Chem. Lett. 2000, 10, 2167).

3. Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

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