Synthesis of enantiomerically pure 4-aryl-3,4-dihydropyrimidin-2(1 H )-ones via enzymatic resolution: preparation of the antihypertensive agent ( R )-SQ 32926 †Synthesis and reactions of Biginelli compounds, part 20; for part 19, see: Kappe, C. O.; Shishkin, O. V.; Uray, G.; Verdino, P. Tetrahedron 2000, 56, 1859–1862. †

Author:

Schnell Barbara,Strauss Ulrike T,Verdino Petra,Faber Kurt,Kappe C.Oliver

Publisher

Elsevier BV

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis

Reference22 articles.

1. For a review on dihydropyrimidones of this type, see: Kappe, C. O. Tetrahedron 1993, 49, 6937–6963.

2. Atwal, K. S.; Rovnyak, G. C.; Kimball, D. S.; Floyd, D. M.; Moreland, S.; Swanson, B. N.; Gougoutas, J. Z.; Schwartz, J.; Smillie, K. M.; Malley, M. F. J. Med. Chem. 1990, 33, 2629–2635.

3. Nagarathanm, D.; Miao, S. W.; Lagu, B.; Chiu, G.; Fang, J.; Dhar, T. G. M.; Zhang, J.; Tyagarajan, S.; Marzabadi, M. R.; Zhang, F. Q.; Wong, W. C.; Sun, W. Y.; Tian, D.; Wetzel, J. M.; Forray, C.; Chang, R. S. L.; Broten, T. P.; Ransom, R. W.; Schorn, T. W.; Chen, T. B.; O’Malley, S.; Kling, P.; Schneck, K.; Bendesky, R.; Harrell, C. M.; Vyas, K. P.; Gluchowski, C. J. Med. Chem. 1999, 42, 4764–4777 and following papers in this series.

4. Mayer, T. U.; Kapoor, T. M.; Haggarty, S.; King, R. W.; Schreiber, S. L.; Mitchison, T. J. Science 1999, 286, 971–974.

5. Bruce, M. A.; Pointdexter, G. S.; Johnson, G. PCT Int. Appl. WO 98 33,791; Chem. Abstr. 1998, 129, 148989g.

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