Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening-Reference-Cited by-同舟云学术

Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening

Published:2020-03 Issue:5 Volume:28 Page:115261
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Carr Miriam,Knox Andrew J.S.,Nevin Daniel K.,O'Boyle Niamh,Wang Shu,Egan Billy,McCabe Thomas,Twamley Brendan,Zisterer Daniela M.,Lloyd David G.,Meegan Mary J.

Funder

Trinity College IITAC research initiative

Enterprise Ireland

Science Foundation Ireland

Wellcome Trust

Research Council Government of Ireland

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference98 articles.

1. Position paper: the membrane estrogen receptor GPER–clues and questions;Barton;Steroids,2012

2. GPER and ER: estrogen receptors with distinct biological roles in breast cancer;Filardo;Immunol Endocrine Metabolic Agents - Med Chem,2011

3. Estrogen-Induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF;Filardo;Mol Endocrinol,2000

4. The G protein-coupled receptor GPR30 mediates c-Fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells;Maggiolini;J Biol Chem,2004

5. The role of estrogen receptor subtypes for vascular maintenance;Luksha;Gynecol Endocrinol,2009

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