Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs-Reference-Cited by-同舟云学术

Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs

Published:2007-08 Issue:16 Volume:15 Page:5519-5528
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Mackman Richard L.,Zhang Lijun,Prasad Vidya,Boojamra Constantine G.,Douglas Janet,Grant Deborah,Hui Hon,Kim Choung U.,Laflamme Genevieve,Parrish Jay,Stoycheva Antitsa D.,Swaminathan Swami,Wang KeYu,Cihlar Tomas

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. Antiviral drugs in current clinical use

2. Tenofovir Disoproxil Fumarate

3. Genotypic and Phenotypic Predictors of the Magnitude of Response to Tenofovir Disoproxil Fumarate Treatment in Antiretroviral‐Experienced Patients

4. Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9- R -(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

5. A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT

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