Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization-Reference-Cited by-同舟云学术

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Published:2009-09 Issue:18 Volume:17 Page:6728-6737
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Tasler Stefan,Müller Oliver,Wieber Tanja,Herz Thomas,Pegoraro Stefano,Saeb Wael,Lang Martin,Krauss Rolf,Totzke Frank,Zirrgiebel Ute,Ehlert Jan E.,Kubbutat Michael H.G.,Schächtele Christoph

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference52 articles.

1. N-substituted 2′-(aminoaryl)benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping

2. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

3. Oncogenic kinase signalling

4. Gefitinib

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