High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept

Author:

Lipinski Christopher A.,Reaume Andrew G.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Tolimidone is the USAN name for Pfizer’s CP-26154. The Chemical Abstracts Service (CAS) name is 2(1H)-Pyrimidinone, 5-(3-methylphenoxy)- and the CAS registry number is 41964-07-2.

2. The lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes;Ochman;J Pharmacol Exp Therap,2012

3. https://medium.com/@johncousins.../how-to-make-your-own-luck-8e76e6db9cc5 [accessed June 6 2019].

4. Pfizer’s CP-22358 has the CAS name of 2(1H)-Pyrimidinone, 5-(phenoxy)- and the CAS registry number is 41963-98-8.

5. Design principles for fragment libraries: maximizing the value of learnings from pharma fragment-based drug discovery (FBDD) programs for use in academia;Keseru;J Med Chem,2016

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