The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists-Reference-Cited by-同舟云学术

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists

Published:2013-12 Issue:24 Volume:21 Page:7628-7647
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Nemoto Toru,Ida Yoshihiro,Iihara Yusuke,Nakajima Ryo,Hirayama Shigeto,Iwai Takashi,Fujii Hideaki,Nagase Hiroshi

Funder

JSPS KAKENHI

Institute of Instrumental Analysis of Kitasato University, School of Pharmacy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference39 articles.

1. Discovery of a Structurally Novel Opioid .KAPPA.-Agonist Derived from 4,5-Epoxymorphinan.

2. Design, synthesis, and structure–activity relationship of novel opioid κ-agonists

3. Opioids in Preclinical and Clinical Trials

4. Pharmacology;Fujii,2012

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology;The Journal of Biochemistry;2024-02-21

2. Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands;Bioorganic & Medicinal Chemistry Letters;2024-02

3. Palladium-catalyzed conversion of phenols into tetrahydroacridines;Green Chemistry;2024

4. C(21)-fluorinated thevinol scaffold for opioid ligands. 21,21,21-Trifluoro-6-O-nororvinols: Design, synthesis and analgesic activity;European Journal of Medicinal Chemistry;2023-04

5. C(21)-Di- and monofluorinated scaffold for thevinol/orvinol-based opioid receptor ligands;Organic & Biomolecular Chemistry;2023