Discovery of spiro[indole-3,2′-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP-Reference-Cited by-同舟云学术

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Discovery of spiro[indole-3,2′-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP

Published:2017-09 Issue:17 Volume:25 Page:4753-4767
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Ito Masahiro,Iwatani Misa,Yamamoto Takeshi,Tanaka Toshio,Kawamoto Tomohiro,Morishita Daisuke,Nakanishi Atsushi,Maezaki Hironobu

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Functions and regulation of the Brr2 RNA helicase during splicing;Absmeier;Cell Cycle,2016

2. Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs;Zhao;Am J Hum Genet,2009

3. The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation;Absmeier;Genes Dev,2015

4. Retinitis pigmentosa mutations of SNRNP200 enhance cryptic splice-site recognition;Cvačková;Hum Mutat,2014

5. Retinitis pigmentosa mutations in bad response to refrigeration 2 (Brr2) impair ATPase and helicase activity;Ledoux;J Biol Chem,2016

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pre‐mRNA Splicing Modulation;Methods and Principles in Medicinal Chemistry;2024-07-05

2. Small molecule inhibition of RNA binding proteins in haematologic cancer;RNA Biology;2024-02-08

3. Direct synthesis of spirooxindoles enabled by palladium-catalyzed allylic alkylation and DBU-mediated cyclization: concept, scope and applications;Organic Chemistry Frontiers;2024

4. Diastereoselective Synthesis of Dispiro[Imidazothiazolotriazine-Pyrrolidin-Oxindoles] and Their Isomerization Pathways in Basic Medium;International Journal of Molecular Sciences;2023-11-15

5. Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2;Acta Crystallographica Section D Structural Biology;2023-04-01

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