Direct synthesis of spirooxindoles enabled by palladium-catalyzed allylic alkylation and DBU-mediated cyclization: concept, scope and applications-Reference-Cited by-同舟云学术

Direct synthesis of spirooxindoles enabled by palladium-catalyzed allylic alkylation and DBU-mediated cyclization: concept, scope and applications

Published:2024 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Tan Fen¹²,He Xiao-Yu²³,Zhou Qiao-Qiao¹,Zhang Ya-Qiong¹,Deng Man²⁴,Yang Qing-Qing³^ORCID,Zou You-Quan²⁴^ORCID

Affiliation:

1. Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, School of Chemistry and Life Sciences, Hubei University of Education, Wuhan, Hubei 430205, China

2. Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan, Hubei 430071, China

3. College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, 8 Daxue Road, Yichang, Hubei 443002, China

4. TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China

Abstract

A concise construction of spiro[indoline-3,2′-pyrrol]-2-one skeletons is reported. This reaction proceeded through a palladium-catalyzed decarboxylative allylic alkylation followed by a DBU-mediated intramolecular cyclization.

Funder

Wuhan University

Natural Science Foundation of Hubei Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO01275E

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4. Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

5. Asymmetric Formal [3+2] Cycloaddition Reactions of 3-Isothiocyanato Oxindoles: an Update