A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation-Reference-Cited by-同舟云学术

A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation

Published:2014-06 Issue:11 Volume:22 Page:2998-3007
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Zhao Wei,Chen Lu,Li Hong-Mei,Wang Duan-Ji,Li Dong-Sheng,Chen Tao,Yuan Zhan-Peng,Tang Ya-Jie

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. Antitumor Properties of Podophyllotoxin and Related Compounds

2. Antitumor Agents. 207. Design, Synthesis, and Biological Testing of 4β-Anilino-2-fluoro-4‘-demethylpodophyllotoxin Analogues as Cytotoxic and Antiviral Agents

3. Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II

4. Antitumor agents. 113. New 4.beta.-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

5. Pharmacodynamics and long-term toxicity of etoposide

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