Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase-Reference-Cited by-同舟云学术

Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase

Published:2005-04 Issue:8 Volume:13 Page:2859-2872
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Levell Julian,Astles Peter,Eastwood Paul,Cairns Jennifer,Houille Olivier,Aldous Suzanne,Merriman Gregory,Whiteley Brian,Pribish James,Czekaj Mark,Liang Guyan,Maignan Sebastien,Guilloteau Jean-Pierre,Dupuy Alain,Davidson Jane,Harrison Trevor,Morley Andrew,Watson Simon,Fenton Garry,McCarthy Clive,Romano Joseph,Mathew Rose,Engers Darren,Gardyan Michael,Sides Keith,Kwong Jennifer,Tsay Joseph,Rebello Sam,Shen Liduo,Wang Jie,Luo Yongyi,Giardino Odessa,Lim Heng-Keang,Smith Keith,Pauls Henry

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

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3. Highlights in Bioorganic Chemistry;Martin,2004

4. Human β-tryptase is a ring-like tetramer with active sites facing a central pore

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