Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa-Reference-Cited by-同舟云学术

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

Published:2009-02 Issue:3 Volume:17 Page:1193-1206
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Nagata Tsutomu,Yoshino Toshiharu,Haginoya Noriyasu,Yoshikawa Kenji,Nagamochi Masatoshi,Kobayashi Syozo,Komoriya Satoshi,Yokomizo Aki,Muto Ryo,Yamaguchi Mitsuhiro,Osanai Ken,Suzuki Makoto,Kanno Hideyuki

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. Guide to anticoagulant therapy. Part 2: Oral anticoagulants. American Heart Association.

2. Role of Thrombin Compared With Factor Xa in the Procoagulant Activity of Whole Blood Clots

3. Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors

4. DX-9065a, a New Synthetic, Potent Anticoagulant and Selective Inhibitor for Factor Xa

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