Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor-Reference-Cited by-同舟云学术

Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor

Published:2011-12 Issue:23 Volume:19 Page:7221-7227
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Kato Noriyasu,Oka Mitsuru,Murase Takayo,Yoshida Masahiro,Sakairi Masao,Yamashita Satoko,Yasuda Yoshika,Yoshikawa Aya,Hayashi Yuuji,Makino Mitsuhiro,Takeda Motohiro,Mirensha Yakufu,Kakigami Takuji

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. On the Physiology of GIP and GLP-1

2. Circulation and Degradation of GIP and GLP-1

3. Biology of Incretins: GLP-1 and GIP

4. The Physiology of Glucagon-like Peptide 1

5. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

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