Design, synthesis, inhibitory activity, and molecular simulations study for <scp>d</scp>-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus-Reference-Cited by-同舟云学术

Design, synthesis, inhibitory activity, and molecular simulations study for d-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Ngoc Toan Vu¹²,Son Hai Do¹³,Thi Kim Van Hoang¹⁴,Minh Tri Nguyen¹²,Ngoc Toan Duong¹⁵,Thi Thanh Mai Nguyen¹⁶,Dinh Thanh Nguyen¹^ORCID

Affiliation:

1. Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Hanoi, Vietnam

2. Academy of Military Science and Technology, Ministry of Defence, Institute of New Technology, 17 Hoang Sam, Cau Giay, Hanoi, Vietnam

3. Ministry of Public Security of Vietnam, Institute of Science and Technology, 47 Pham Van Dong, Cau Giay, Hanoi, Vietnam

4. Faculty of Chemical Technology, Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Vietnam

5. Faculty of Chemistry, Thai Nguyen University of Education, 20 Luong Ngoc Quyen, Thai Nguyen, Vietnam

6. Faculty of Chemical Technology, Ha Noi University of Industry, 298 Cau Dien Road, North Tu Liem, Hanoi, Vietnam

Abstract

d-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00334A

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