Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety-Reference-Cited by-同舟云学术

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Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety

Published:2015-12 Issue:24 Volume:23 Page:7765-7776
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Zhang Hao,Xin Min-Hang,Xie Xiao-Xiao,Mao Shuai,Zuo Sai-Jie,Lu She-Min,Zhang San-Qi

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2. Tenets of PTEN Tumor Suppression

3. Targeting the phosphoinositide 3-kinase pathway in cancer

4. PI3K and cancer: lessons, challenges and opportunities

5. Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review;Current Topics in Medicinal Chemistry;2024-08-19

2. Synthetic Methodologies and SAR of Quinazoline Derivatives as PI3K Inhibitors;Anti-Cancer Agents in Medicinal Chemistry;2023-05

3. Synthesis of Quinazolin-4(3H)-ones via a novel approach;Journal of Saudi Chemical Society;2023-03

4. Synthesis and Anti-Cancer Applications of Benzimidazole Derivatives - Recent Studies;Anti-Cancer Agents in Medicinal Chemistry;2022-11

5. Recent Advances in PI3 Kinase Inhibitors: Anticancer Activities and Structure-Activity Relationships;Mini-Reviews in Medicinal Chemistry;2022-09

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