Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists-Reference-Cited by-同舟云学术

Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists

Published:2019-06 Issue:11 Volume:27 Page:2220-2227
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Teno Naoki,Yamashita Yukiko,Masuda Arisa,Iguchi Yusuke,Oda Keisuke,Fujimori Ko,Hiramoto Takie,Nishimaki-Mogami Tomoko,Une Mizuho,Gohda Keigo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference33 articles.

1. Identification of a nuclear receptor for bile acids;Makishima;Science,1999

2. Bile acids: Natural ligands for an orphan nuclear receptor;Parks;Science,1999

3. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR;Wang;Mol Cell,1999

4. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis;Sinal;Cell,2000

5. Bile acid transporters;Dawson;J Lipid Res,2009

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unveiling structural determinants for FXR antagonism in 1,3,4-trisubstituted-Pyrazol amide derivatives: A multi-scale in silico modelling approach;Computers in Biology and Medicine;2024-09

2. FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice;Biological and Pharmaceutical Bulletin;2024-08-13

3. Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights;Molecules;2024-04-27

4. Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation;European Journal of Medicinal Chemistry;2024-04

5. Synthesis of Pyrazolone Derivatives by Grinding, Microwave, and Conventional Techniques and Their Antimicrobial Activity;Russian Journal of Organic Chemistry;2022-06