Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist ‘CJ-17,493’-Reference-Cited by-同舟云学术

Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist ‘CJ-17,493’

Published:2008-08 Issue:15 Volume:16 Page:7193-7205
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Shishido Yuji,Wakabayashi Hiroaki,Koike Hiroki,Ueno Naomi,Nukui Seiji,Yamagishi Tatsuya,Murata Yoshinori,Naganeo Fumiharu,Mizutani Mayumi,Shimada Kaoru,Fujiwara Yoshiko,Sakakibara Ayano,Suga Osamu,Kusano Rinko,Ueda Satoko,Kanai Yoshihito,Tsuchiya Megumi,Satake Kunio

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Tachykinin NK1receptor antagonists for the control of chemotherapy-induced nausea and vomiting

2. Peripheral tachykinin receptors as potential therapeutic targets in visceral diseases

3. Neurokinin antagonists and their potential role in treating depression and other stress disorders

4. Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

5. Ito, F.; Kondo, H.; Shimada, K.; Nakane, M.; Lowe III, J. A.; Rosen, T. J.; Yang, B. V. WO 9221677 A1.

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