N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)-Reference-Cited by-同舟云学术

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N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

Published:2012-12 Issue:24 Volume:20 Page:7175-7183
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Sabbah Dima A.,Simms Neka A.,Wang Wang,Dong Yuxiang,Ezell Edward L.,Brattain Michael G.,Vennerstrom Jonathan L.,Zhong Haizhen A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference49 articles.

1. Signaling by Distinct Classes of Phosphoinositide 3-Kinases

2. The emerging mechanisms of isoform-specific PI3K signalling

3. The Phosphoinositide 3-Kinase Pathway

4. The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

5. Helical domain and kinase domain mutations in p110 of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

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4. Novel Derivatives of 4,6‐Dihydroxy‐2‐Quinolone‐3‐Carboxamides as Potential PI3Kα Inhibitors;ChemistrySelect;2022-08-23

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