Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase-Reference-Cited by-同舟云学术

Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase

Published:2016-05 Issue:9 Volume:24 Page:2097-2107
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Sun Guohui^ORCID,Zhang Na,Zhao Lijiao,Fan Tengjiao,Zhang Shufen,Zhong Rugang

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing

Beijing Municipal Education Commission Science and Technology Project

Beijing University of Technology

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference50 articles.

1. A Critical Appraisal of the Evolution of N-Nitrosoureas as Anticancer Drugs

2. DNA Cross-Linking Agents as Antitumor Drugs

3. First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-grade astrocytomas

4. Phase II trial of intratumoral BCNU injection and radiotherapy on untreated adult malignant glioma

5. DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response

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