Synthesis and biological evaluation of novel N3- substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel N3- substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain

Published:2017-03 Issue:6 Volume:25 Page:1926-1938
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Teleb Mohamed,Zhang Fang-Xiong,Huang Junting,Gadotti Vinicius M.,Farghaly Ahmed M.,AboulWafa Omaima M.,Zamponi Gerald W.,Fahmy Hesham

Funder

The Egyptian Ministry of Higher Education and Scientific Research

Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University

Canadian Institutes of Health Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference57 articles.

1. 1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain

2. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats

3. Role of voltage-gated calcium channels in ascending pain pathways

4. T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome

5. T-type voltage-gated calcium channels as targets for the development of novel pain therapies

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