Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors

Author:

Gamal Hassan1,Ismail Khadiga A.12,Omar A-Mohsen M. E.1,Teleb Mohamed1,Abu-Serie Marwa M.3,Huang Sun4,Abdelsattar Abdalla S.5,Zamponi Gerald W.4,Fahmy Hesham6

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

2. Faculty of Pharmacy, Alamein International University (AIU), Alamein City, Egypt

3. Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt

4. Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

5. Center for Microbiology and Phage Therapy, Zewail City of Sciences and Technology, October Gardens, Giza, Egypt

6. Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, South Dakota State University, Brookings, SD, USA

Funder

Technology & Innovation Funding Authority (STIFA) for funding this work through the Young Researcher Grant

Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Sciences, South Dakota State University

Canadian Institutes of Health Research

Alberta Innovates

Canada Research Chair

Publisher

Informa UK Limited

Reference119 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung H;CA Cancer J Clin,2021

2. Latest world cancer statistics – GLOBOCAN 2012: Estimated cancer incidence Mortality and Prevalence Worldwide in 2012 – IARC. [cited 2022 Dec 9]. https://www.iarc.who.int/news-events/latest-world-cancer-statistics-globocan-2012-estimated-cancer-incidence-mortality-and-prevalence-worldwide-in-2012/.

3. Non–Small Cell Lung Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology;Ettinger DS;J Natl Compr Canc Netw,2022

4. Institute NC. PDQ Adult Treatment Editorial Board. Non-Small Cell Lung Cancer Treatment (PDQ®): Health Professional Version. 2020 [cited 2022 Dec 9]; https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq.

5. Cisplatin- versus carboplatin-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer: an individual patient data meta-analysis;Ardizzoni A;J Natl Cancer Inst,2007

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