Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility-Reference-Cited by-同舟云学术

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility

Published:2014-12 Issue:23 Volume:22 Page:6570-6585
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Rzasa Robert M.,Frohn Michael J.,Andrews Kristin L.,Chmait Samer,Chen Ning,Clarine Jeffrey G.,Davis Carl,Eastwood Heather A.,Horne Daniel B.,Hu Essa,Jones Adrie D.,Kaller Matthew R.,Kunz Roxanne K.,Miller Silke,Monenschein Holger,Nguyen Thomas,Pickrell Alexander J.,Porter Amy,Reichelt Andreas,Zhao Xiaoning,Treanor James J.S.,Allen Jennifer R.

Funder

Office of Science, Office of Basic Energy Sciences, Materials Sciences Division

U.S. Department of Energy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

2. Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment

3. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

4. Sildenafil in the treatment of pulmonary hypertension

5. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

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