Put a ring on it: application of small aliphatic rings in medicinal chemistry-Reference-Cited by-同舟云学术

Put a ring on it: application of small aliphatic rings in medicinal chemistry

Published:2021 Issue:4 Volume:12 Page:448-471
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Bauer Matthias R.¹²³⁴⁵,Di Fruscia Paolo¹²³⁴⁵,Lucas Simon C. C.¹²³⁴⁵^ORCID,Michaelides Iacovos N.¹²³⁴⁵^ORCID,Nelson Jennifer E.¹²³⁴⁵^ORCID,Storer R. Ian¹²³⁴⁵,Whitehurst Benjamin C.¹²³⁴⁵^ORCID

Affiliation:

1. Discovery Sciences

2. BioPharmaceuticals R&D

3. AstraZeneca

4. Cambridge

5. UK

Abstract

Aliphatic small rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry. This review summarises judicious successful application and reported limitations of these ring systems.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00370K

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