Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring-Reference-Cited by-同舟云学术

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Published:2019-04 Issue:8 Volume:27 Page:1747-1758
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Yamamoto Naoshi,Ohrui Sayaka,Okada Takahiro,Saitoh Tsuyoshi,Kutsumura Noriki,Nagumo Yasuyuki,Irukayama-Tomobe Yoko,Ogawa Yasuhiro,Ishikawa Yukiko,Watanabe Yurie,Hayakawa Daichi,Gouda Hiroaki,Yanagisawa Masashi,Nagase Hiroshi

Funder

JSPS

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

3. The role of orexin in motivated behaviours

4. Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

5. The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia

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