Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1-Reference-Cited by-同舟云学术

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Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1

Published:2019-12 Issue:24 Volume:27 Page:115159
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Feng Jiangtao,He Haifeng,Zhou Yuan,Cai Meng,Peng Hao,Liu Honglin,Liu Lei,Feng Lingling,He Hongwu

Funder

Natural Science Foundation of China

National Research and Development Plan

Project of the Science Fund of Jiangxi Education Office

Project of Hubei Natural Science Foundation

China Postdoctoral Science Foundation

CCNU

Program of Introducing Talents of Discipline to Universities of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. Mitigating cyanobacterial harmful algal blooms in aquatic ecosystems impacted by climate change and anthropogenic nutrients;Paerl;Harmful Algae,2016

2. Mitigating harmful cyanobacterial blooms in a human- and climatically-impacted world;Paerl;Life,2014

3. The profound effect of harmful cyanobacterial blooms: From food-web and management perspectives;Šulčius;Sci Total Environ,2017

4. Gender-specific toxicological effects of chronic exposure to pure microcystin-LR or complex microcystis aeruginosa extracts on adult medaka fish;Le Manach;Environ Sci Technol,2016

5. Harmful cyanobacterial blooms: causes, consequences, and controls;Paerl;Microbial Ecol,2013

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1. Trans-Cinnamaldehyde Inhibition of Pyruvate Dehydrogenase: Effects on Streptococcus mutans Carbohydrate Metabolism;Journal of Proteome Research;2024-07-22

2. Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase;Bioorganic & Medicinal Chemistry Letters;2024-01

3. Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation;Bioorganic Chemistry;2023-09

4. Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues;ACS Medicinal Chemistry Letters;2023-04-11

5. Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis;Organic & Biomolecular Chemistry;2023

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