Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents-Reference-Cited by-同舟云学术

Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents

Published:2018-11 Issue:20 Volume:26 Page:5470-5478
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Pavana Roheeth Kumar,Shah Khushbu,Gentile Taylor,Dybdal-Hargreaves Nicholas F.,Risinger April L.,Mooberry Susan L.,Hamel Ernest,Gangjee Aleem

Funder

National Institutes of Health

NCI

COSTAR

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Hallmarks of Cancer: The Next Generation

2. The cytoskeleton and cancer

3. Interphase microtubules: chief casualties in the war on cancer?

4. Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale

5. How Do Microtubule-Targeted Drugs Work? An Overview

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Five-membered ring fused pyrimidine-based derivatives and their biological properties;Fused Pyrimidine-Based Drug Discovery;2023

2. An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint;Mini-Reviews in Medicinal Chemistry;2022-10

3. Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development;Pharmacology & Therapeutics;2021-09

4. Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents;Bioorganic & Medicinal Chemistry Letters;2021-06

5. The Use of Conformational Restriction in Medicinal Chemistry;Current Topics in Medicinal Chemistry;2019-10-21